Povorcitinib for treating hidradenitis suppurativa

Povorcitinib is in clinical development for the treatment of moderate to severe hidradenitis suppurativa (HS) in adults. HS is a painful, long-term skin condition that causes skin abscesses and scarring on the skin. As time goes by, more and more scarring appears. It can have a significant impact on a person’s everyday life. The exact cause of HS is unknown, but it occurs near hair follicles where there are sweat glands, usually around the groin, bottom, breasts, and armpits. HS abscesses are usually painful and may make it uncomfortable to sit or move one’s arms. Discharge of pus can be a problem and may require daily dressings. HS can have a severe psychological effect such as depression and can sometimes be associated with inflammation of the joints
(arthritis). Many patients with HS may be unresponsive to current treatment options. Therefore, there is a high need for new treatments for this population.