Olorofim for invasive fungal infections

Olorofim is currently in development for the treatment of invasive fungal infections caused by rare moulds. Scedosporiosis (including lomentosporiosis) is an infection caused by a group of fungi called Scedosporium species (a rare mould). These moulds are often spread by spores in the environment, which can be inhaled or get inside the skin and spread locally, invading the blood vessels, which causes infection. They are usually seen in patients with a weakened immune system, and it is often resistant to many antifungal medicines. They are life-threatening infections that can be fatal due to damage to the lungs and other organs. The symptoms can include shortness of breath, cough, fever, and chest pain. Resistance to existing treatments is a growing challenge in the management of these rare moulds and invasive fungal infections.