Glycopyrronium bromide cream for treating severe primary axillary hyperhidrosis

One percent glycopyrronium bromide (GPB) cream has been developed for the treatment of severe primary axillary hyperhidrosis (severe underarm sweating, which has no obvious cause). Patients with primary axillary hyperhidrosis (PAHH), suffer from an excessive amount of sweat production in the armpits when the body does not need to cool down. Severe PAHH strongly affects the patient’s quality of life, interfering with daily activities and causing anxiety and embarrassment. Current treatment options are associated with considerable adverse events such as skin irritation, dry mouth, and compensatory sweating. There is therefore a need for additional treatments which avoid these whilst improving quality of life.