Dupilumab for treating Prurigo Nodularis

Dupilumab is in clinical development for the treatment of prurigo nodularis (PN) for people who have not responded to or cannot have corticosteroid treatment. PN is a chronic skin disorder in which people have firm, raised bumps on the skin known as nodules. The nodules are very itchy and itching the affected area can worsen the condition. The causes of PN are not fully understood, but it is thought that overreaction of the body’s immune system may be responsible for the disease. External reasons for the development of PN are not clear, but it may be caused by insect bites, prolonged stress and other related conditions such as asthma and eczema.