Deutetrabenazine for treating tardive dyskinesia

Tardive dyskinesia is a chronic disorder characterised by involuntary stereotyped, choreic (jerky and unpredictable), athetoid (slow and writhing), and/or dystonic (sustained or repetitive) movements in one or more areas of the body, including the orofacial region (e.g., tongue thrusting, lip smacking and/or pursing, grimacing), extremities (e.g., stereotypic piano-playing movements,
flexion/extension of the ankles or toes), and torso (e.g., pelvic rocking). It is a late (tardive) complication commonly associated with long-term use of certain medications, particularly antipsychotics. The reasons that some people who take these medicines may get tardive
dyskinesia, and some people do not, is unknown. For patients suffering from tardive dyskinesia, these uncontrolled movements can be disruptive and disabling, significantly impacting their quality of life. There are limited treatment options available for the management of tardive dyskinesia, and no clear standard of care.