Baxdrostat for treating uncontrolled hypertension including resistant hypertension

Baxdrostat is in clinical development for the treatment of uncontrolled hypertension including resistant hypertension (high blood pressure). The cause of high blood pressure is not always clear, however, it can be due to lifestyle factors such as having a poor diet, being overweight, smoking and eating too much salt. Sometimes it can be caused by medications or other issues such as vascular disease, kidney disease or sleep apnoea. Resistant hypertension is defined as blood pressure that remains high even after using three or more different types of medication. It does not always have symptoms and when they do occur, they include headaches, shortness of breath and chest pain. Uncontrolled or resistant hypertension substantially increases the risk of a heart attack, stroke and kidney failure.