Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
LAM-561 in addition to radiation therapy and temozolomide for glioblastoma –adjuvant	2-hydroxyoleic acid (2-OHOA; LP561A1; LAM561) , Radiotherapy , Temozolomide (Temodar; Temodal; SCH 52365)	Glioma	Neurological Cancer	2021	View \| Download
Lacosamide for primary generalised tonic-clonic seizures – adjunctive therapy	Lacosamide (Vimpat)	Epilepsy	Neurology	2019	View \| Download
L-glutamine for Sickle Cell Disease	L-glutamine (Xyndari)	Sickle cell disease (SCD)	Haematology	2018	View \| Download
KTE-C19 for Relapsed/Refractory B-precursor Acute Lymphocytic Leukaemia in Adults	Brexucabtagene autoleucel (Tecartus; KTE-X19)	Acute lymphoblastic leukaemia (ALL)	Haematological Cancer and Lymphomas	2018	View \| Download
KTE-C19 for relapsed or refractory mantle cell lymphoma	Axicabtagene Ciloleucel (Yescarta; KTE-C19)	Mantle cell lymphoma	Haematological Cancer and Lymphomas	2017	View \| Download
Kaftrio (Elexacaftor/tezacaftor/ivacaftor) and ivacaftor for treating cystic fibrosis in children (2 to 5 years) with at least one F508del mutation in the CFTR gene	Kaftrio (fixed dose combination: Elexacaftor; Tezacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2022	View \| Download
JZP-458 for acute lymphoblastic leukaemia and lymphoblastic lymphoma	JZP-458 (RC-P; Recombinant Erwinia asparaginase)	Acute lymphoblastic leukaemia (ALL) , Lymphoblastic lymphoma (LBL)	Haematological Cancer and Lymphomas	2020	View \| Download
JNJ-68284528 for relapsed or refractory multiple myeloma	Ciltacabtagene Autoleucel (JNJ-68284528; LCAR-B38M CAR-T cell therapy; LCAR-B38M; JNJ 4528)	Multiple myeloma (MM)	Haematological Cancer and Lymphomas	2020	View \| Download
Ixekizumab for axial spondyloarthritis	Ixekizumab (Taltz; LY2439821)	Spondyloarthritis	Musculoskeletal System , Rheumatology	2018	View \| Download
Ixazomib citrate for newly diagnosed multiple myeloma inelgible for autologous stem cell transplant– maintenance therapy	Ixazomib (Ninlaro; MLN 9708; MLN 2238; ixazomib citrate)	Multiple myeloma (MM)	Haematological Cancer and Lymphomas	2019	View \| Download