Search All Tech Briefings

Search technology briefings produced by NIHR Innovation Observatory. These are short reports on new or repurposed medicines that we have already sent to our stakeholders. Only those technologies (medicines) that are within the scope of our stakeholders will have a technology briefing available. Search our technology briefings by intervention (drug or device), specific indication (disease or condition), or general therapeutic area.

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Title	Intervention	Indication	Therapeutic Area	Year	Actions
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del CFTR mutation in patients aged 2-5 years old	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Lumacaftor and Ivacaftor (Orkambi) for Cystic Fibrosis Homozygous for the F508del Mutation in Patients Aged 6‐11 Years	Orkambi (fixed dose combination: Lumacaftor; Ivacaftor)	Cystic fibrosis	Genetic Disorders , Respiratory System	2018	View \| Download
Lumasiran for primary hyperoxaluria type 1 in paediatric patients aged up to 5 years	Lumasiran (ALN-GO1)	Primary hyperoxaluria	Nephrology	2019	View \| Download
Lumasiran for primary hyperoxaluria type I	Lumasiran (ALN-GO1)	Primary hyperoxaluria	Nephrology	2019	View \| Download
Lumateperone for acute exacerbations of psychosis in schizophrenia	Lumateperone (ITI-722; ITI-007)	Schizophrenia	Mental and Behavioural Health	2017	View \| Download
Lurbinectedin for platinum resistant ovarian cancer	Lurbinectedin (PM01183; Zepzelca)	Epithelial ovarian cancer , Fallopian tube cancer , primary peritoneal cancer	Female Reproductive Cancer	2017	View \| Download
Lurbinectedin in addition to doxorubicin for small-cell lung cancer after prior platinum-containing therapy	Doxorubicin (Livatag; BA-003; Caelyx; Sarcodoxome; SP-1049C; Resmycin; JNS002; doxorubicin hydrochloride) , Lurbinectedin (PM01183; Zepzelca)	Small-cell lung cancer (SCLC)	Lung and Respiratory Cancer	2020	View \| Download
Lurbinectedin with atezolizumab maintenance therapy for extensive-stage small-cell lung cancer	Atezolizumab (Tecentriq; MPDL3280A) , Lurbinectedin (PM01183; Zepzelca)	Small-cell lung cancer (SCLC)	Lung and Respiratory Cancer	2023	View \| Download
Luspatercept for adult patients with beta-thalassemia who require red blood cell transfusions	Luspatercept (ACE-536; Reblozyl)	Beta thalassemia	Genetic Disorders , Haematology	2018	View \| Download
Luspatercept for myelodysplastic syndromes (MDS) associated anaemia	Luspatercept (ACE-536; Reblozyl)	Anaemia due to myelodysplastic syndromes (MDS)	Haematological Cancer and Lymphomas , Haematology	2018	View \| Download