02 September 2025

Final Report: Horizon Scan for Bowel Cancer Screening Tests

This horizon scan provides an overview of blood-based biopsy tests for screening bowel cancer currently in clinical development globally. We present information regarding the types of upcoming tests, the developers, geographical locations of clinical trials along with the technology readiness of the identified tests.

Bowel cancer is a prevalent cancer worldwide and, in the UK, with its burden is projected to increase significantly by 2030. Early detection is critical for improving survival rates. Currently a screening test, Faecal Immunochemical Test (FIT), is used for screening bowel cancer, which if positive is followed with a colonoscopy. Emerging blood-based liquid biopsies may be used as non-invasive options following a positive FIT to determine the need for colonoscopy and therefore present a promising option to be used in tandem with current FIT screening. Knowledge regarding the types of upcoming tests, might facilitate strategy and policy for implementation in the UK.

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