Repurposed Medicines for Viruses With Epidemic or Pandemic Potential: A Horizon Scan

This horizon scan examines investigational activity surrounding repurposed medicines for viruses of epidemic or pandemic concern, including Ebola, Marburg, influenza, mpox, MERS-CoV, SARS-CoV, and SARS-CoV-2. It maps current research and clinical development trends involving UK- and EU-licensed medicines being explored for antiviral use. It highlights the diversity of pharmacological approaches under investigation, including direct-acting antivirals, immunomodulators, and anti-inflammatory agents, while also emphasising the importance of robust preclinical validation and pharmacokinetic feasibility before clinical translation.

The findings provide valuable insights into the evolving antiviral repurposing landscape and may help inform future epidemic or pandemic preparedness and therapeutic research strategies.